GETTING MY METHADONE CLINIC JOBS TO WORK

[sixty one] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with diverse potency. Dextromethadone, which is much less powerful being an opioid, is much more powerful at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, w